Publications by authors named "Sarah M Kedziora"
Article Synopsis
- Microvascular imaging is becoming crucial for diagnosing and treating various diseases, highlighting the need to study how different organs communicate through their vascular systems.
- A new perfusion protocol has been developed to effectively deliver a contrast agent to the micro-vessels of multiple organs in the same animal model, ensuring consistency and repeatability in the process.
- The research also focuses on optimizing image acquisition by balancing shorter scanning times with high spatial resolution, resulting in a robust protocol for investigating vascular health and disease across different organs.
The placenta is a temporary organ with a unique structure and function to ensure healthy fetal development. Placental dysfunction is involved in pre-eclampsia (PE), fetal growth restriction, preterm birth, and gestational diabetes mellitus (GDM). A diabetic state affects maternal and fetal health and may lead to functional alterations of placental metabolism, inflammation, hypoxia, and weight, amplifying the fetal stress.
View Article and Find Full Text PDFAims/hypothesis: The impact of diabetic pregnancy has been investigated extensively regarding offspring metabolism; however, little is known about the influence on the heart. We aimed to characterise the effects of a diabetic pregnancy on male adult offspring cardiac health after feeding a high-fat diet in an established transgenic rat model.
Methods: We applied our rat model for maternal type 2 diabetes characterised by maternal insulin resistance with hyperglycaemia and hyperinsulinaemia.
Preeclampsia (PE) is characterized by the onset of hypertension (≥140/90 mmHg) and presence of proteinuria (>300 mg/L/24 h urine) or other maternal organ dysfunctions. During human PE, renal injuries have been observed. Some studies suggest that women with PE diagnosis have an increased risk to develop renal diseases later in life.
View Article and Find Full Text PDFSeveral studies show an association of maternal diabetes during pregnancy with adverse offspring metabolic health. Other studies, however, suggest that this effect might be biased by obesity, which is independently associated with offspring metabolic disease and often coexistent to maternal diabetes. We performed a prospective study in a rat model to test the hypothesis that the burden of a diabetic pregnancy without obesity deteriorates metabolic health in male offspring.
View Article and Find Full Text PDF