Publications by authors named "Sarah M Azer"
Cystinuria is the most common genetic cause of recurrent kidney stones. As the result of a genetic defect in proximal tubular reabsorption of filtered cystine, increased urine levels of the poorly soluble amino acid result in recurrent cystine nephrolithiasis. Recurrent cystine stones not only adversely affect the quality of patients suffering from cystinuria but also may result in chronic kidney disease (CKD) from recurrent renal injury.
View Article and Find Full Text PDFContext: CYP24A1 encodes 24-hydroxylase, which converts 25(OH)D3 and 1,25(OH)D to inactive metabolites. Loss-of-function variants in CYP24A1 are associated with 24-hydroxylase deficiency (24HD), characterized by hypercalcemia, nephrolithiasis, and nephrocalcinosis. We retrospectively reviewed laboratory, imaging, and clinical characteristics of patients with suspected or confirmed 24HD and patients with other vitamin D-mediated hypercalcemia disorders: sarcoidosis, lymphoma, and exogenous vitamin D toxicity (EVT).
View Article and Find Full Text PDFIntroduction: Hemostatic prophylaxis (HP) is recommended for patients with bleeding disorders (PWBD) before invasive procedures. However, evidence-based guidelines are needed to determine optimal HP strategies.
Aim: To determine outcomes of HP for PWBD undergoing colonoscopy.
Article Synopsis
- The study aimed to find effective oral antidotes for cyanide poisoning, as traditional methods are limited by the inability to conduct human trials.
- The researchers tested sodium thiosulfate's effectiveness in rabbits, revealing that immediate oral administration significantly improved survival rates compared to controls.
- Their findings suggest that using sodium thiosulfate, especially combined with glycine and administered soon after cyanide ingestion, could be a viable treatment for cyanide poisoning in humans.