Publications by authors named "Sarah M Alaniz"
Robust preclinical models of asymmetric ventricular loading in late gestation reflecting conditions such as hypoplastic left heart syndrome are lacking. We characterized the morphometry and microvascular function of the hypoplastic left ventricle (LV) and remaining right ventricle (RV) in a sham-controlled late gestation fetal lamb model of impaired left ventricular inflow (ILVI). Singleton fetuses were instrumented at ∼120 days gestational age (dGA; term is ∼147 days) with vascular catheters, an aortic flow probe and a deflated left atrial balloon.
View Article and Find Full Text PDFBirth is associated with substantial shifts in cardiovascular physiology. Little is known about coronary vascular adaptations during this period. We used fetal and neonatal lambs to measure coronary function at late gestation (92% of term) and shortly after birth (5-6 days postnatal age).
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates how microvascular perfusion in striated muscle changes from late gestation to early neonate, revealing that perfusion significantly decreases in neonates compared to late-term fetuses, although flow reserve remains unchanged.
- - Researchers used contrast-enhanced ultrasound perfusion imaging on lambs at late gestation and shortly after birth to measure various aspects of muscle perfusion and oxygen delivery.
- - The findings indicate that striated muscle capillary networks develop more slowly than the muscle fibers they supply during the perinatal period, highlighting an important aspect of muscle health and development post-birth.