Biopharmaceutical profiling of anti-infective sanggenons from root bark for inhalation administration.

Mulberry Diels-Alder-type adducts (MDAAs), isolated from root bark, exhibit dual activity against viral and bacterial pathogens but show sobering efficacy following oral administration. Inhalation administration may overcome issues with oral bioavailability and improve efficacy for the treatment of respiratory infections. To assess the suitability of MDAAs for inhalation administration, physicochemical (e.

Investigating experimental vs. Predicted pK values for PET radiotracer.

The prediction of central nervous system (CNS) active pharmaceuticals and radiopharmaceuticals has experienced a boost by the introduction of computational approaches, like blood-brain barrier (BBB) score or CNS multiparameter optimization values. These rely heavily on calculated pK values and other physicochemical parameters. Despite the inclusion of various physicochemical parameters in online data banks, pK values are often missing and published experimental pK values are limited especially for radiopharmaceuticals.