Publications by authors named "Sarah LeBlanc"
Background And Aims: Endoscopy makes a significant contribution to the carbon footprint of healthcare. A randomized trial (RESECT-COLON) demonstrated that Endoscopic Submucosal Dissection (ESD) decreases the recurrence rate of large adenomas (>25 mm) versus piecemeal Endoscopic Mucosal Resection (P-EMR), reducing the need for follow-up colonoscopy. We aimed to compare the carbon footprint of those 2 strategies.
View Article and Find Full Text PDFBackground And Aims: Endoscopic ultrasound-guided pelvic abscess drainage (EUS-PAD) with lumen-apposing metal stents (LAMS) is an alternative approach for post-surgical and inflammatory pelvic collections. We assess the safety and efficacy of EUS-PAD with LAMS in a large population of complicated acute diverticulitis (AD).
Methods: We retrieved consecutive patients who underwent EUS drainage attempts for complicated AD from 2019-2023 in three referral centers.
Breaking the cycle: Memorable messages of "grin n' bear it" and silence in menarche narrative recall.
Qual Res Med Healthc
July 2024
To better understand adolescent experiences of menstruation, the CODE Red project was initiated to examine period poverty and menstruation stigma. As part of the project, a survey was posted online through Qualtrics, and the link was posted to social media sites. One hundred and eighty-seven individuals completed the open-ended questionnaire between January and August 2022.
View Article and Find Full Text PDFBackground And Aims: We aimed to evaluate the feasibility, safety and efficacy of endoscopic submucosal dissection for recurrent rectal neoplastic lesions after transanal microsurgery of superficial rectal neoplasms.
Methods: Multicenter retrospective study.
Main Outcomes: recurrence at first endoscopic follow-up, En bloc, R0 and curative resections.
Introduction: The adoption of colorectal endoscopic submucosal dissection (ESD) is still limited in the West. A recent randomized trial showed that ESD is more effective and only slightly riskier than piecemeal endoscopic mucosal resection; reproducibility outside expert centers was questioned. We evaluated the results according to the annual case volume in a multicentric prospective cohort.
View Article and Find Full Text PDFArticle Synopsis
- * The French Association for the Study of the Liver created guidelines to summarize the best practices for managing iCCA and pCCA, based on comprehensive expert analysis and voting.
- * These guidelines cover the epidemiology of cholangiocarcinoma and outline management strategies from diagnosis to treatment, emphasizing advancements in personalized medicine and targeted therapies.
Background: We assessed efficacy and safety of endoscopic ultrasound-guided biliary drainage (EUS-BD) vs. endoscopic retrograde cholangiopancreatography (ERCP) as first-line intervention in malignant distal biliary obstruction (MDBO).
Methods: PubMed/Medline, Embase, and Cochrane databases were searched until 01 /12 /2023 for randomized controlled trials of EUS-BD vs.
School nurses and menstrual communication: Destigmatizing the stigma among adolescents.
Womens Health (Lond)
May 2024
Objective: The purpose of this study is to understand how school nurses, often the first line of defense for menstruating adolescents, use communication to assist adolescents in destigmatizing menstruation.
Design: I conducted semi-structured narrative interviews with nine nurses employed in a large school district in Northeast Indiana.
Methods: Interviews were coded, categorized, and used a phronetic iterative approach.
This collaborative autoethnography explores the experiences of women academics and mothers who received late diagnoses of Attention Deficit Hyperactivity Disorder (ADHD). Due to the historical underdiagnosis of women, little research has focused on this specific demographic. We shed light on how ADHD presents in women, interweaving our stories with extant literature and emphasizing the need to understand this demographic's experiences better.
View Article and Find Full Text PDFBackground: Endoscopic resection of adenomas prevents colorectal cancer, but the optimal technique for larger lesions is controversial. Piecemeal endoscopic mucosal resection (EMR) has a low adverse event (AE) rate but a variable recurrence rate necessitating early follow-up. Endoscopic submucosal dissection (ESD) can reduce recurrence but may increase AEs.
View Article and Find Full Text PDFWhat distinguishes endoscopic submucosal dissection (ESD) from endoscopic mucosal resection is the need for three foot pedals to activate the electrosurgical unit, flushing and knife injection. The lack of connection between the various pedals of different shapes and brands leads to numerous pedals displacements and potential mistakes. The aim of this study was to evaluate an Innovative PEdal FIXator (IPEFIX) to reduce pedal mistakes during ESD.
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- The study examines the impact of surgically addressing non-R0 resections of rectal neuroendocrine tumors (r-NETs) to prevent disease recurrence.
- It involved a retrospective analysis of 100 patients who underwent endoscopic procedures to remove tumor scars after initial unsuccessful resections.
- The findings indicate that using advanced endoscopic techniques achieved near 100% complete resection (R0) of scars, revealing that residual r-NET was present in 43% of cases.
INTRODUCTION : Residual colorectal neoplasia (RCN) after previous endoscopic mucosal resection is a frequent challenge. Different management techniques are feasible including endoscopic full-thickness resection using the full-thickness resection device (FTRD) system and endoscopic submucosal dissection (ESD). We aimed to compare the efficacy and safety of these two techniques for the treatment of such lesions.
View Article and Find Full Text PDFBackground And Aims: Endoscopic submucosal dissection (ESD) is challenging for appendicular lesions. We report the outcomes of ESD in this context.
Methods: We collected data of ESD procedures for appendiceal neoplasia in a multicenter prospective registry.
BACKGROUND : The diagnosis of cholangiocarcinoma in patients with a biliary stricture without mass syndrome can be obtained by biliary brushing with a sensitivity of ~50 %. We performed a multicenter randomized crossover trial comparing the aggressive Infinity brush with the standard RX Cytology Brush. The aims were to compare sensitivity for cholangiocarcinoma diagnosis and cellularity obtained.
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- Esophageal stricture is a common complication following endoscopic resection for early esophageal cancers, with current prevention methods being largely ineffective and causing significant side effects.
- Researchers conducted a study to analyze transcript changes in patients at risk for strictures, focusing on the differences between those who developed strictures and those who did not by examining biopsies taken at specific intervals.
- The study found that on Day 14, there was increased activity of the interleukin-1 group and decreased activity of interferon-gamma and NUPR1 in patients with strictures, suggesting that targeting IL-1 or supplementing INFγ may offer new prevention strategies for this condition.
Background And Objectives: The background of this study was to evaluate the outcomes of perihilar cholangiocarcinoma (pCCA) patients treated with EUS-guided hepaticogastrostomy (EUS-HGS).
Methods: All patients with pCCA who underwent EUS-HGS from 2010 to 2020 were analyzed. The primary outcome was clinical success; the secondary outcomes were technical success, adverse events (AEs), stent patency, and oncological outcomes.
Article Synopsis
- Variants in the PRSS1 and PRSS2 genes are linked to chronic pancreatitis (CP), prompting research into whether a deletion variant affecting two trypsinogen pseudogenes (PRSS3P2 and TRY7) might influence CP risk.
- A study analyzed this deletion in over 4,000 participants from different countries and found that it is associated with a protective effect against CP, especially in French, German, and Japanese populations.
- The research suggests that the deletion enhances the function of remaining genes, leading to regulated PRSS2 expression, which could be crucial in understanding CP susceptibility.
Article Synopsis
- EUS-nCLE is effective for diagnosing pancreatic cystic lesions (PCLs), showing high interobserver agreement (κ = 0.82) and intra-observer reliability.
- The accuracy for differentiating mucinous from non-mucinous PCLs is 94.8%, with excellent performance in identifying specific subtypes like serous cystadenoma and cystic neuroendocrine tumors.
- Overall, EUS-nCLE demonstrates a reliable and accurate approach for diagnosing PCLs via a "virtual biopsy" method.
Article Synopsis
- - Preclinical studies indicate that off-target effects from RNA interference contribute significantly to hepatotoxicity in GalNAc-siRNA conjugates.
- - Researchers developed a new strategy called enhanced stabilization chemistry plus (ESC+) which effectively reduces off-target binding while preserving the intended on-target effects in RNA therapies.
- - This approach was successfully applied to ALN-HBV, leading to a redesigned version (ALN-HBV02) with better specificity and safety, allowing it to resume clinical development.
Article Synopsis
- Short interfering RNAs (siRNAs) have been successfully used in liver therapies, but there’s a need for new delivery methods to target other organs.
- Conjugating siRNAs with 2'-O-hexadecyl (C16) allows effective gene silencing in the central nervous system, eye, and lung, showing sustained effects for at least 3 months in animal studies.
- A study targeting amyloid precursor protein in a mouse model of Alzheimer's demonstrated that C16-siRNAs can improve both physiological and behavioral symptoms, indicating potential for broader therapeutic applications.