Publications by authors named "Sarah L Phillips"
Article Synopsis
- Natural killer (NK) cells play a crucial role in attacking intracellular infections and cancer, and their activity is leveraged in oncolytic virus (OV) therapy to boost anti-tumor immunity.
- Research on reovirus, a type of oncolytic virus, shows that it activates human NK cells through type I interferon (IFN-I) signaling, enhancing their ability to kill tumor cells while impacting their proliferation.
- Despite the activation of NK cells, treatment with reovirus led to a temporary decrease in certain NK cell subsets in circulation, suggesting they relocate to lymphoid tissues where they can better coordinate immune responses against tumors.
