Amino Acid Availability Is Not Essential for Life-Span Extension by Dietary Restriction in the Fly.

Dietary restriction (DR) is one of the most potent ways to extend health and life span. Key progress in understanding the mechanisms of DR, and aging more generally, was made when dietary protein, and more specifically essential amino acids (EAA), were identified as the dietary component to restrict to obtain DR's health and life-span benefits. This role of dietary amino acids has influenced work on aging mechanisms, especially in nutrient sensing, for example, Target of Rapamycin and insulin(-like) signaling networks.