Publications by authors named "Sarah Kuburi"
Evidence suggests young adults in post-secondary school experienced increased distress during the COVID-19 pandemic, but students' experiences likely varied. Effects may have also changed over time as students adapted. This study examined the mental health of students with and without preexisting health conditions at two points during the pandemic (winter 2020/2021 and spring/summer 2021).
View Article and Find Full Text PDFThis prospective longitudinal study measured sex-specific changes in depression, anxiety, and stress scores using, validated Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and the Perceived Stress Scale (PSS) in a cohort of 1445 post-secondary students (500 males, 945 females) assessed at three time points from December 2020 to January 2022. Participants were ascertained from a population of 15,585 students with in-person activities on campus at baseline and recruited from December 2020 to January 2021. We also assessed how sociodemographic characteristics influenced students' mental health outcomes.
View Article and Find Full Text PDFPain and depression frequently co-occur. Due to its antidepressant and analgesic properties, ketamine has been used for the management of treatment-resistant depression and pain. This systematic review examined the literature on the efficacy of sub-anesthetic doses of ketamine in individuals experiencing comorbid depression and chronic pain (CDCP), as well as comorbid depression and acute pain (CDAP).
View Article and Find Full Text PDFFunctional neuroimaging research suggests that the amygdala is implicated in the pathophysiology of major depressive disorder (MDD). This systematic review aimed to identify consistently reported amygdala activity and functional connectivity (FC) abnormalities in antidepressant-free participants with MDD as compared to healthy controls at baseline (i.e.
View Article and Find Full Text PDFArticle Synopsis
- Preliminary evidence suggests psychedelics could be effective for treating major depressive disorder (MDD) but research on their neural mechanisms is limited.
- A systematic review analyzed neuroimaging correlates of antidepressant responses to psychedelics, focusing on studies involving psilocybin, ayahuasca, and LSD, and found significant brain activity and connectivity changes linked to treatment outcomes.
- The review highlights the default mode and limbic networks as potential areas for future exploration and emphasizes the need for more extensive research to verify these initial findings, as they are based on a small number of datasets.