A cohort study of cucumber greenhouse workers' exposure to microorganisms as measured using NGS and MALDI-TOF MS and biomarkers of systemic inflammation.

Work in greenhouses entails exposure to airborne fungi and bacteria. The aims of this study are to obtain knowledge about whether exposure to fungal and bacterial genera and species during work in a cucumber greenhouse is affected by work tasks, and whether a cohort of greenhouse workers' serum levels of serum amyloid A (SAA) and C-reactive protein (CRP), biomarkers of systemic inflammation, are associated with this. Data on personal exposure to airborne fungal and bacterial species measured over 4 years as well as serum levels of SAA and CRP sampled over two years were analyzed.

Treatment of pain in SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome.

SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome includes a variety of musculoskeletal disorders and associated skin conditions. Diagnosis can be difficult but should be considered in the differential in patients with lytic, sclerotic, or hyperostotic bone lesions and pain. Appropriate and prompt treatment, including use of nonsteroidal medications such as ibuprofen or naproxen, colchicine, corticosteroids, and bisphosphonates, and use of disease-modifying agents such as methotrexate, sulfasalazine and infliximab, can produce improvement of symptoms.