Synthesis and in vitro evaluation shows disquaramide compounds are a promising class of anti-leishmanial drugs.

An increasing number of treatment failures with current pharmaceutics, as well as a lack of a vaccine, demonstrates the need to develop new treatment options for leishmaniasis. Herein, we describe the synthesis and in vitro analysis of 24 disquaramide compounds targeting the parasite. Of the compounds that were evaluated, six of them ( , , , , , and ) were capable of significantly decreasing the number of parasites by up to 42% compared to the control by day four.

Effect of surface modification on silica supported Ti catalysts for cyclohexene oxidation with vapor-phase hydrogen peroxide.

Surface modification grafting of organic moieties on a Lewis acid catalyst (silica supported Ti catalyst, Ti-SiO) alters the activation of HO in vapor-phase cyclohexene epoxidation. Grafting a fluorous group (1,1-perfluoro-octyl) suppresses activity of Ti-SiO. Conversely, grafting either a nonpolar group (octyl) or a polar aprotic group (triethylene glycol monomethyl ether) enhances rates and shifts selectivity toward -1,2-cyclohexanediol.