Publications by authors named "Sarah J Riddell"
Article Synopsis
- Buruli ulcer (BU) is a skin disease caused by the bacterium Mycobacterium ulcerans, which is increasingly seen in Australia where possums serve as a reservoir for the infection.
- In a study, six wild-caught possums that had never been exposed to MU were injected and all developed BU, with ulceration occurring between 49 and 77 days after infection.
- The findings revealed systemic infection signs in most possums, indicating that this model can enhance understanding of how the bacterium spreads and can inform strategies to prevent further transmission and outbreaks.
Hendra and Nipah viruses (family Paramyxoviridae, genus Henipavirus) are bat-borne viruses that cause fatal disease in humans and a range of other mammalian species. Gaining a deeper understanding of host pathways exploited by henipaviruses for infection may identify targets for new anti-viral therapies. Here we have performed genome-wide high-throughput agonist and antagonist screens at biosafety level 4 to identify host-encoded microRNAs (miRNAs) impacting henipavirus infection in human cells.
View Article and Find Full Text PDF