Synopsis of recent research by authors named "Sarah J Hartman"
- Sarah J Hartman's recent research primarily focuses on exploring innovative therapeutic approaches for difficult-to-treat cancers, including acral and mucosal melanomas, pancreatic ductal adenocarcinoma, and microsatellite-stable colorectal cancer, by utilizing targeted genomic profiling and novel drug combinations.
- Her studies highlight the identification of potentially targetable genomic alterations in acral and mucosal melanomas, as well as the efficacy of combining agents like pembrolizumab, binimetinib, and bevacizumab in overcoming resistance to immunotherapy in colorectal cancer patients.
- Hartman also investigates the role of specific signaling pathways, such as Wnt signaling and immune modulation, in enhancing cancer treatment effectiveness, using both preclinical models and human immune system mouse models to assess therapeutic potential.
