Publications by authors named "Sarah J Foran"
Background: Patients with acute traumatic cervical or high thoracic level spinal cord injury (SCI) typically require mechanical ventilation (MV) during their acute admission. Placement of a tracheostomy is preferred when prolonged weaning from MV is anticipated. However, the optimal timing of tracheostomy placement in patients with acute traumatic SCI remains uncertain.
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- - Overexpression of SKI, a TGF-β repressor, deactivates the fibrotic myofibroblast phenotype in the heart by both inhibiting TAZ and activating the Hippo tumor-suppressor pathway, independently of SMAD/TGF-β signaling.
- - The study utilized a rat model and primary rat cardiac fibroblast cultures to analyze TAZ expression and SKI's effects, using various techniques like qPCR, luciferase assays, and mass spectrometry to explore SKI's mechanisms of action.
- - Results indicate that SKI specifically degrades TAZ through the proteasome, influencing actin dynamics to inhibit myofibroblast activation, while BioID2 interactomics reveal potential
Purpose: Reirradiation is rarely administered to patients with recurrent craniopharyngioma owing to concerns regarding visual and endocrine side effects. The purpose of this case series was to evaluate our institutional experience of patients with craniopharyngioma treated with 2 courses of fractionated radiation therapy.
Methods And Materials: A retrospective study was performed of all patients with craniopharyngioma treated with 2 courses of fractionated radiation therapy at a single institution.