Publications by authors named "Sarah Hoelzl"
Article Synopsis
- The lncRNA Crossfirre is an X-linked gene that is transcribed opposite to another lncRNA called Firre, and together with Dxz4, they form significant chromatin structures specific to inactive X chromosomes.
- Researchers carried out large-scale knockout studies of Crossfirre, Firre, and Dxz4 to understand their in vivo roles, finding that although these loci have unique epigenetic traits, they are not crucial for X chromosome inactivation processes.
- The study reveals that Crossfirre influences the regulation of autosomal genes, but only in conjunction with Firre, and includes a phenotyping analysis that highlights various knockout and sex-specific outcomes.
