Seasonal variability in energetic value of Crangon alaskensis and effects of marine heatwaves in the Northeast Pacific Ocean.

Research cruises were conducted to sample the invertebrate community along the shelf off the central coast of Oregon from 2010 to 2018. A large marine heatwave (MHW) hit the northeast Pacific in fall 2014 and persisted locally through 2015. Here, we assessed the caloric content changes of Crangon alaskensis (a common sandy shrimp) before, during, and after the 2014-2015 MHW.

Long-term liver transplant outcomes for progressive familial intrahepatic cholestasis type 1: The Pittsburgh experience.

Background: Progressive familial intrahepatic cholestasis type 1 (PFIC1) arises from biallelic variants in the ATP8B1 gene that annul FIC1 activity, resulting in progressive liver disease. Liver transplant (LT) is indicated in refractory disease; however, post-LT complications including worsening diarrhea and steatohepatitis progressing to fibrosis with graft loss have been reported. We aim to describe long-term outcomes of PFIC1 LT recipients at our center, focusing on the histological changes of the allografts.

Pharmacological management of portal hypertension and its complications in children: lessons from adults and opportunities for the future.

Introduction: Portal hypertension (PHT) and its complications in children are thought to be distinct from adult PHT in several areas, including the underlying bio-physiology of a child in which PHT develops, but also because of the pediatric-specific etiologies that drive disease progression. And yet pharmacologic approaches to PHT in children are mainly based on adult data, modified for pediatric practice. This reality has been driven by a lack of data specific to children.

Expanding etiology of progressive familial intrahepatic cholestasis.

Background: Progressive familial intrahepatic cholestasis (PFIC) refers to a disparate group of autosomal recessive disorders that are linked by the inability to appropriately form and excrete bile from hepatocytes, resulting in a hepatocellular form of cholestasis. While the diagnosis of such disorders had historically been based on pattern recognition of unremitting cholestasis without other identified molecular or anatomic cause, recent scientific advancements have uncovered multiple specific responsible proteins. The variety of identified defects has resulted in an ever-broadening phenotypic spectrum, ranging from traditional benign recurrent jaundice to progressive cholestasis and end-stage liver disease.

Video sleds effectively survey epibenthic communities at dredged material disposal sites.

This research assessed the effectiveness of benthic video sleds for monitoring the impacts of dredged material disposal on epifauna at shallow and deep water disposal sites near the mouth of the Columbia River, USA. Video sleds collected visual transects at the two disposal sites and comparable reference areas during 2014 and 2015 within a Before-After, Control-Impact (BACI) experimental design. These flat, soft-bottom habitats are populated by demersal fish and benthic invertebrates, including the economically important Dungeness crab (Cancer magister).

Assessment of spatial patterns in benthic macrofauna of the U.S. west coast continental shelf.

Aim: We assessed whether currently described marine biogeographic boundaries apply to shelf macrofauna and which environmental drivers were most associated with species differences among regions.

Location: Pacific coast of North America from the Strait of Juan de Fuca in Washington to the California-Mexico border.

Methods: Van Veen grab samples were collected from soft sediment 28-138 m deep and sieved using 1 mm mesh.

Assessing differences in macrofaunal assemblages as a factor of sieve mesh size, distance between samples, and time of sampling.

With increasing cascading effects of climate change on the marine environment, as well as pollution and anthropogenic utilization of the seafloor, there is increasing interest in tracking changes to benthic communities. Macrofaunal surveys are traditionally conducted as part of pre-incident environmental assessment studies and post-incident monitoring studies when there is a potential impact to the seafloor. These surveys usually characterize the structure and/or spatiotemporal distribution of macrofaunal assemblages collected with sediment cores; however, many different sampling protocols have been used.

Leptin enhances the potency of circulating angiogenic cells via src kinase and integrin (alpha)vbeta5: implications for angiogenesis in human obesity.

Objective: To investigate the capacity of the adipokine leptin to promote angiogenesis by modulating the function of circulating angiogenic cells (CACs).

Methods And Results: In vitro, leptin specifically promoted CAC adhesion to tubular endothelial structures and migration along outgrowing sprouts of endothelial cells. In vivo, stimulation of CACs with leptin increased their capacity to promote new vessel formation in the chorioallantoic membrane of chicken embryos and to improve neovascularization of ischemic murine hind limbs.