Publications by authors named "Sarah Hampe"
Cyclooxygenase-2 (COX-2) is a key regulator of inflammation. High constitutive expression enhances survival and proliferation of cancer cells, and adversely impacts antitumor immunity. The expression of is modulated by various signaling pathways.
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- The TRPM7 protein plays a dual role as a cation channel and kinase, impacting thymopoiesis and cytokine expression in immune cells.
- Research using kinase-dead mutant mice reveals that TRPM7's enzymatic activity is crucial for the gut-homing of specific T cells (intra-epithelial lymphocytes) and their ability to express the molecule CD103.
- The study suggests that regulating TRPM7 kinase activity can influence T cell differentiation and potentially offers new therapeutic strategies for conditions like acute graft-versus-host disease.
The immune system protects our body against foreign pathogens. However, if it overshoots or turns against itself, pro-inflammatory diseases, such as rheumatoid arthritis, inflammatory bowel disease, or diabetes develop. Ions, the most basic signaling molecules, shape intracellular signaling cascades resulting in immune cell activation and subsequent immune responses.
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