[Infectious diseases through some major western comics].

Infectious diseases played a key role in public health development during the 20th century and well-known western comics such as Asterix, The Adventures of Tintin and Lucky Luke are of major significance to the local collective imagination. The purpose of the present review is to establish how infectious diseases were addressed in Goscinny, Hergé and Morris's comics by systematically gathering all references to infectiology throughout the series. It emerged that many allusions to transmittable diseases could be found in The Adventures of Tintin whereas Asterix and Lucky Luke, whose historical frameworks differ from the ones of the authors, rarely mention any contagious diseases.

The use of silver diamine fluoride (SDF) in dental practice.

Silver diamine fluoride (SDF) is a clear, odourless liquid indicated for desensitisation of non-carious tooth lesions and molar incisor hypomineralisation. It is also useful for arresting carious lesions in adults and children who are high caries-risk and/or have difficult-to-control, progressing carious lesions, those who are unable to tolerate invasive treatment, elderly populations, and those who are medically compromised or have additional care and support needs. SDF may be used to manage lesions that are too extensive to restore but not associated with pain and/or infection.

CRM1-dependent trafficking of retroviral Gag proteins revisited.

We analyzed the nuclear trafficking ability of Gag proteins from six retroviral genera. Contrary to a previous report, human immunodeficiency virus type 1 (HIV-1) Gag showed no propensity to cycle through the nucleus. The only Gag protein that displayed CRM1-dependent nuclear cycling was that of Rous sarcoma virus (RSV).

Two distinct mechanisms regulate recruitment of murine leukemia virus envelope protein to retroviral assembly sites.

The cytoplasmic tail domain (CTD) of retroviral envelope (Env) proteins has been implicated in modulating Env incorporation into viral particles. We generated a panel of murine leukemia virus (MLV) Env mutants and analyzed their ability to be recruited to human immunodeficiency virus-1 (HIV-1) assembly sites. Surprisingly, the entire CTD was dispensable for recruitment to assembly sites, but a mutation that disrupted the furin cleavage site in Env abolished recruitment.