Publications by authors named "Sarah Garnier"
Introduction: Childhood chronic diseases affect family functioning and well-being. The aim of this study was to measure the impact of caring for a child with PUV, and the factors that most impact the burden of care.
Patients And Method: We gave a questionnaire on the familial impact of having a child with posterior urethral valves to all parents of a child included in the CIRCUP trial from 2015 onwards.
Objective: Boys with posterior urethral valves (PUV) present an increased risk of febrile urinary tract infection (fUTI). Identifying specific risk factors could allow for tailoring UTI prevention. The aim of this study was to use the data from the CIRCUP randomized controlled trial data to identify patient characteristics associated with a higher risk of fUTI.
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- Smooth Muscle Cells (SMCs) can change their behavior and functionality, switching between a relaxed state and a more active, proliferative state, which can be linked to dysfunction.
- In a study of infants with chronic intestinal pseudo-obstruction (CIPO), it was found that SMCs had reduced contractile markers and increased levels of a receptor called PDGFRA, indicating a shift towards a less differentiated state.
- Understanding this phenotypic change in CIPO-SMCs could lead to new therapeutic strategies aimed at encouraging these cells to differentiate properly and improve gut motility.
Objective: To determine which patients should benefit from the interposition of a well-vascularized flap between the neourethra and the penile skin and if it should be performed even in mild hypospadias.
Patients And Methods: A retrospective study on patients with a primary hypospadias repair was performed (2003-2017). Only patients undergoing urethroplasty based on the principle of a tubularization were selected to ensure comparable groups.
Article Synopsis
- - The study evaluated the prognosis of torsion of healthy ovaries (THO) compared to torsion with underlying ovarian masses (TUOM) in children, finding a significant difference in outcomes.
- - Out of 54 girls analyzed, THO was linked to a higher risk of ovarian hypotrophy or atrophy compared to TUOM, particularly with a notable difference in cases diagnosed after puberty.
- - The findings suggest that THO tends to lead to worse outcomes due to less clear initial diagnoses and hormonal factors, highlighting the importance of timely intervention.
Objectives: In Hirschsprung disease (HD), despite successful surgical treatment, 50% of children experience long-term functional gastrointestinal problems, particularly chronic functional obstructive symptoms. We report our experience regarding clinical effects of neurostimulation-guided anal intrasphincteric botulinum toxin (BT) injections on postoperative obstructive symptoms attributed to a nonrelaxing anal sphincter complex in HD patients.
Methods: In this monocenter cohort study, 15 HD patients with postoperative functional intestinal obstructive symptoms received neurostimulation-guided anal intrasphincteric BT injections.
Article Synopsis
- A study investigated the prevalence and familial patterns of hypospadias, finding that family histories of the condition were more common than expected, with 22.3% of affected boys having a family connection.
- Familial cases often involved paternal relatives and were not associated with higher rates of premature birth or other congenital issues compared to sporadic cases.
- Genetic analysis suggested that familial cases had a higher frequency of genetic defects than isolated cases, indicating that even mild forms of hypospadias warrant thorough family history assessments for better understanding and management.
Objectives: In-vitro experiments on ormocers (ORganically MOdified CERamics) have provided controversial results. Consequently, the objectives of this meta-analysis were to (1) compare clinical performances of first generation ormocers versus conventional composite restorations, (2) explore the influence of various clinical factors and the impact of the quality of studies on published results.
Methods: The following databases were explored until 2017/01/08: Ovid MEDLINE In-Process, Pubmed, CENTRAL, HTA, DARE, LILACS and Google Scholar.
Objectives: To evaluate the outcomes of hypospadias surgery according to age and to determine if some complications are age-related.
Patients And Methods: This retrospective study was based on 722 boys with hypospadias undergoing primary repair. A total of 501 boys underwent urethroplasty and were included in the study.
Pheochromocytomas and paragangliomas (PHEO/PGL) are neuroendocrine tumors that arise from sympathetic and parasympathetic paraganglia. Although well described in the adult population, diagnosis and treatment of these exceptionally rare neoplasms remains poorly characterized in children. This article reviews recent advances in clinical presentation, genetics, biochemistry, imaging and treatment of children with benign or malignant PHEO/PGL.
View Article and Find Full Text PDFObjective: Bilateral surgery has been largely advocated in premature boys with unilateral inguinal hernia owing to the high incidence of contralateral patent processus vaginalis. Recently, the potential morbidity of herniotomy in low birth-weight babies and the progress in pediatric anesthesia questioned this attitude. This study aims to evaluate the incidence of contralateral metachronous hernia in a large series of premature boys and to compare the morbidity of preventive versus elective surgery.
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- Mesoblastic nephroma is the most common type of fetal tumor in the kidneys, but this report is about a rare case of intrarenal neuroblastoma found before birth.
- A 30-week-old fetus had an unusual mass in its kidney seen during an ultrasound, and after birth, doctors found the baby had high blood pressure and heart issues.
- After surgery to remove the tumor, tests showed it was neuroblastoma, and doctors suggest that certain signs like high blood pressure and specific chemicals in urine could help detect such tumors in the future.