Publications by authors named "Sarah Fagan"
Article Synopsis
- ABO blood group and inherited gene mutations can affect pancreatic cancer risk in first-degree relatives (FDRs) of pancreatic cancer patients, but their combined impact is still unclear.
- Research of 23,739 FDRs showed a higher cancer risk linked to mutation-positive probands, with a significant increase compared to those who were mutation-negative (3.80 vs. 1.79 risk ratio).
- Overall, while ABO blood group alone did not significantly alter cancer risk levels, FDRs of mutation-positive probands with non-O blood types exhibited the highest risk.
Epidemiologic Research of Rare Cancers: Trends, Resources, and Challenges.
Cancer Epidemiol Biomarkers Prev
July 2021
Background: The goals of this project were to assess the status of NCI's rare cancer-focused population science research managed by the Division of Cancer Control and Population Sciences (DCCPS), to develop a framework for evaluation of rare cancer research activities, and to review available resources to study rare cancers.
Methods: Cancer types with an overall age-adjusted incidence rate of less than 20 cases per 100,000 individuals were identified using NCI Surveillance, Epidemiology and End Results (SEER) Program data. SEER data were utilized to develop a framework based on statistical commonalities.
Utilizing SEER Cancer Registries for Population-Based Cancer Survivor Epidemiologic Studies: A Feasibility Study.
Cancer Epidemiol Biomarkers Prev
September 2020
Background: While the primary role of central cancer registries in the United States is to provide vital information needed for cancer surveillance and control, these registries can also be leveraged for population-based epidemiologic studies of cancer survivors. This study was undertaken to assess the feasibility of using the NCI's Surveillance, Epidemiology, and End Results (SEER) Program registries to rapidly identify, recruit, and enroll individuals for survivor research studies and to assess their willingness to engage in a variety of research activities.
Methods: In 2016 and 2017, six SEER registries recruited both recently diagnosed and longer-term survivors with early age-onset multiple myeloma or colorectal, breast, prostate, or ovarian cancer.
The purpose of this study is to explore existing research on determinants of cervical cancer screening among immigrants and refugees in the U.S. A scoping review was conducted on 77 studies targeting immigrant and/or refugee women in the U.
View Article and Find Full Text PDFBackground: Increased risk of malignancies other than pancreatic cancer (PC) has been reported among first-degree relatives (FDRs) of PC patients; however, the roles of susceptibility gene mutations are unclear. We assessed risk for 15 cancers among FDRs of unselected PC probands.
Methods: Data on 17 162 FDRs, with more than 336 000 person-years at risk, identified through 2305 sequential PC probands enrolled at Mayo Clinic (2000-2016) were analyzed.