Publications by authors named "Sarah E Raby-Buck"
Chitin-derived furans offer a sustainable alternative feedstock for nitrogen appended aromatic compounds. Herein, we address the challenge of using chitin-derived furans, 3-acetamido-5-acetylfuran (3A5AF) and 3-acetamido-5-furfural aldehyde (3A5F), to favour the formation of exo Diels-Alder adducts and 4-acetylaminophthalimides respectively, using a mechanochemical ball-milling technique. Mechanochemical activation is explored through the synthesis of 7-oxa-norbornene backbones with novel substitution pattern from 3A5AF in yields up to 77 % and improved exo:endo selectivity compared to solution-phase reactions.
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- A novel method for catalyzing the Suzuki-Miyaura coupling reaction using nickel was developed, focusing on aryl sulfamates and boronic acids.
- The process is environmentally friendly, being solvent-free and conducted under air, while utilizing a programmable temperature control system for consistency.
- This method can be scaled up significantly, achieving a 200-fold increase in production using twin-screw extrusion, leading to the creation of larger quantities of the desired materials.