Publications by authors named "Sarah E R Yablonski"
Cerium oxide (CeO) nanoparticles (CeNPs) are potent antioxidants that are being explored as potential therapies for diseases in which oxidative stress plays an important pathological role. However, both beneficial and toxic effects of CeNPs have been reported, and the method of synthesis as well as physico-chemical, biological, and environmental factors can impact the ultimate biological effects of CeNPs. In the present study, we explored the effect of different ratios of citric acid (CA) and EDTA (CA/EDTA), which are used as stabilizers during synthesis of CeNPs, on the antioxidant enzyme-mimetic and biological activity of the CeNPs.
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- The study investigates the differences in RNA expression between corneas from patients with keratoconus (KC) and healthy controls, using advanced RNA sequencing techniques.
- A total of 436 coding RNAs and 584 long noncoding RNAs were found to have significant differential expression, highlighting genes linked to cell migration and other biological processes.
- The results suggest specific genes and pathways that could play important roles in the development of keratoconus, potentially guiding future research and therapeutic strategies.