A dynamic simulation framework for CT perfusion in stroke assessment built from first principles.

Purpose: Physicians utilize cerebral perfusion maps (e.g., cerebral blood flow, cerebral blood volume, transit time) to prescribe the plan of care for stroke patients.

Accurate Image Domain Noise Insertion in CT Images.

Tools to simulate lower dose, noisy computed tomography (CT) images from existing data enable protocol optimization by quantifying the trade-off between patient dose and image quality. Many studies have developed and validated noise insertion techniques; however, most of these tools operate on proprietary projection data which can be difficult to access and can be time consuming when a large number of realizations is needed. In response, this work aims to develop and validate an image domain approach to accurately insert CT noise and simulate low dose scans.