Intracoronary and systemic melatonin to patients with acute myocardial infarction: protocol for the IMPACT trial.

Introduction: Ischaemia-reperfusion injury following acute myocardial infarctions (AMI) is an unavoidable consequence of the primary percutaneous coronary intervention (pPCI) procedure. A pivotal mechanism in ischaemia-reperfusion injury is the production of reactive oxygen species following reperfusion. The endogenous hormone, melatonin, works as an antioxidant and could potentially minimise the ischaemia-reperfusion injury.

Prototype phantoms for characterization of ultralow field magnetic resonance imaging.

Purpose: Prototype phantoms were designed, constructed, and characterized for the purpose of calibrating ultralow field magnetic resonance imaging (ULF MRI) systems. The phantoms were designed to measure spatial resolution and to quantify sensitivity to systematic variation of proton density and relaxation time, T1 .

Methods: The phantoms were characterized first with conventional magnetic resonance scanners at 1.