Association of non-malignant diseases with thrombocytosis: a prospective cohort study in general practice.

Background: Thrombocytosis is an excess of platelets, which is diagnosed as a platelet count >400 × 10/l. An association of thrombocytosis with undiagnosed cancer has recently been established, but the association with non-malignant disease has not been studied in primary care.

Aim: To examine, in English primary care, the 1-year incidence of non-malignant diseases in patients with new thrombocytosis and the incidence of pre-existing non-malignant diseases in patients who develop new thrombocytosis.

Cancer incidence following a high-normal platelet count: cohort study using electronic healthcare records from English primary care.

Background: A raised platelet count (thrombocytosis) measuring >400 × 10/l is associated with high cancer incidence. It is uncertain whether platelet counts at the upper end of the normal range (high-normal: 326-400 × 10/l) are also associated with cancer.

Aim: To investigate cancer incidence following a normal platelet count in primary care.

Microcytosis as a risk marker of cancer in primary care: a cohort study using electronic patient records.

Background: Microcytosis (smaller than normal red blood cells) has previously been identified as a possible early risk marker for some cancers. However, the role of microcytosis across all cancers has not been fully investigated.

Aim: To examine cancer incidence in a cohort of patients with microcytosis, with and without accompanying anaemia.

Clinical relevance of thrombocytosis in primary care: a prospective cohort study of cancer incidence using English electronic medical records and cancer registry data.

Background: Thrombocytosis (raised platelet count) is an emerging risk marker of cancer, but the association has not been fully explored in a primary care context.

Aim: To examine the incidence of cancer in a cohort of patients with thrombocytosis, to determine how clinically useful this risk marker could be in predicting an underlying malignancy.

Design And Setting: A prospective cohort study using Clinical Practice Research Datalink data from 2000 to 2013.

How useful is thrombocytosis in predicting an underlying cancer in primary care? a systematic review.

Background: Although the association between raised platelet count (thrombocytosis) and cancer has been reported in primary and secondary care studies, UK GPs are unaware of it, and it is insufficiently evidenced for laboratories to identify and warn of it. This systematic review aimed to identify and collate evidence from studies that have investigated thrombocytosis as an early marker of cancer in primary care.

Methods: EMBASE (OvidSP), Medline (Ovid), Web of Science and The Cochrane Library were searched for relevant studies.

Allergy education in otolaryngology residency: a survey of program directors and residents.

Background: The purpose of this study was to survey program directors of the accredited otolaryngology residency programs and resident attendees of the 2013 American Academy of Otolaryngic Allergy (AAOA) Basic/MOC Course regarding resident education and participation as well as assessment of competency in otolaryngic allergy and immunotherapy.

Methods: A multiple-choice questionnaire was sent to all accredited otolaryngology residency training programs in the United States as part of resident attendance at the 2013 AAOA CORE Basic/MOC Course. Following this, a similar multiple-choice survey was sent to all resident attendees from the programs that responded positively.

HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives.

(1,1-Dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives have been investigated as potential anti-HCV drugs. Their synthesis, HCV NS5B polymerase inhibition, and replicon activity are discussed.

Successful cryopreservation of mouse oocytes by using low concentrations of trehalose and dimethylsulfoxide.

Sugars such as trehalose, sucrose, and glucose are effectively used by a variety of animals (e.g., brine shrimp, tardigrades, some frogs, and insects), as well as by bacteria, yeasts, and plant seeds to survive freezing and extreme drying.