Publications by authors named "Sarah Dillender"
Glycation alters the mechanical behavior of kidney extracellular matrix.
Matrix Biol Plus
November 2020
Article Synopsis
- The extracellular matrix (ECM) plays a crucial role in normal body function, and its mechanical properties can change with aging and diseases like diabetes, impacting overall health.
- One key modification occurs through non-enzymatic reactions between sugars and ECM proteins, leading to the formation of advanced glycation end products (AGEs) that affect ECM stiffness.
- Research indicates that increased sugar levels can significantly alter the mechanical properties of kidney ECM, with potential implications for the progression of diabetic kidney disease due to increased stiffness and crosslinking of ECM components.