Publications by authors named "Sarah Chute"
J Immunother Cancer
January 2023
Article Synopsis
- Researchers are investigating non-invasive biomarkers to diagnose immune checkpoint inhibitor-associated acute tubulointerstitial nephritis (ICI-nephritis), focusing on markers of immune dysregulation linked to CTLA4 deficiency.
- The study compared sIL-2R levels and cell-based markers from patients with ICI-nephritis against various control groups, revealing that sIL-2R levels were significantly elevated in patients with ICI-nephritis.
- A specific sIL-2R cutoff of 1.75-fold above the normal limit was found to be a strong indicator for diagnosing ICI-nephritis.
