Publications by authors named "Sarah Christine Schock"
Pediatr Dev Pathol
August 2012
Article Synopsis
- The study evaluates the effectiveness of GAP-43 as a marker for Hirschsprung disease, comparing it to calretinin, which is already established as a specific marker.
- GAP-43 was found to strongly stain nerve fibers in ganglionic segments, but not in aganglionic segments, indicating its presence in both types of tissue yet a weakness in distinguishing aganglionic segments.
- Findings suggest that while GAP-43 marks mucosal nerve fibers in both ganglionic and aganglionic intestines, it is less reliable than calretinin for diagnosing Hirschsprung disease and calls for further research on the properties of these mucosal nerves.
