Publications by authors named "Sarah C Beck"

Aims: At a tissue level, matrix metalloproteinase-1 (MMP-1) and transforming growth factor-beta 1 (TGF-β1) contribute to allergic airway inflammation, tissue remodelling and disease severity in asthma via different pathways. Their peripheral blood levels and role in diagnosis and therapeutic monitoring has not been adequately explored. We investigated the association between MMP-1 and TGF-β in moderate and severe persistent asthma and evaluated their performance characteristics by constructing receiver operating characteristic curves.

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Article Synopsis
  • * Various studies on MCT testing have shown inconsistent results due to differing definitions of anaphylaxis, testing methods, and when samples are collected, but recent guidelines have been developed for interpreting these tests, especially in cases related to anesthesia.
  • * There is ongoing research into new biomarkers for anaphylaxis that may improve diagnosis and understanding of the condition, including factors like sample handling and cost, as well as potential applications of metabolomics and systems biology for better
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Background: Mild oropharyngeal symptoms to peanut/hazelnut occur in ~30% of patients with pollen-food syndrome (PFS). Component tests are considered a useful adjunct to the diagnosis and may help differentiate PFS from those at a risk of anaphylaxis due to storage protein/lipid transfer protein (LTP) sensitisation.

Aims: To assess concordance between component tests and clinical history in suspected PFS to peanut/hazelnut in a specialist clinic.

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'Measurement uncertainty of measured quantity values' (ISO15189) requires that the laboratory shall determine the measurement uncertainty for procedures used to report measured quantity values on patients' samples. Where we have numeric data measurement uncertainty can be expressed as the standard deviation or as the co-efficient of variation. However, in immunology many of the assays are reported either as semi-quantitative (i.

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