Publications by authors named "Sarah Brooks"

Article Synopsis
  • Atopic dermatitis (AD) is an inflammatory skin condition affecting about 25% of children, often continuing into adulthood and proving challenging to control with current treatments.
  • Recent research highlights the varying nature of AD among different age groups and ethnicities, indicating a need for tailored treatment approaches based on specific disease characteristics.
  • Promising strategies for future AD management include exploring treatments that target the microbiome, immune responses, and neural functions to achieve better long-term symptom relief.
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  • * It often manifests in specific forms such as brachioradial pruritus in the forearms, notalgia paresthetica in the upper back, and anogenital itch, which can be related to spine problems.
  • * Treatment may involve topical remedies or systemic medications, but currently, there are no FDA-approved options specifically for neuropathic itch, making it essential to understand its neural causes for effective management.
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  • Cough and itch are essential protective responses, helping to expel irritants from the body, but can lead to chronic conditions that diminish quality of life.
  • The article explores the mechanisms behind chronic cough and chronic itch, highlighting their similarities and differences to develop new treatment options.
  • A comprehensive review of literature revealed shared triggers, nervous system processing, and immune responses for both cough and itch, suggesting that therapies targeting these neuroimmune pathways could benefit both conditions.
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Article Synopsis
  • Atopic dermatitis (AD) is a long-lasting skin condition that causes inflammation and itching, significantly affecting patients’ quality of life.
  • Managing itch is essential for improving outcomes in AD patients, as it can be challenging to treat due to its complex causes and various symptoms.
  • The article discusses new treatments being tested for their safety and effectiveness in reducing itch associated with AD, focusing on both topical and systemic options.
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  • The acid mantle is a protective buffer system in the upper layer of the skin that helps maintain an acidic environment, which is important for skin health.
  • Skin pH plays a critical role in maintaining the epidermal barrier, and changes in pH can lead to skin issues and influence dermatological diseases.
  • The review discusses how skin pH affects skin conditions and suggests that therapies targeting pH levels could improve the treatment of these conditions.
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  • Pruritus is a distressing itch that leads to scratching, which can negatively impact quality of life, causing issues like sleep problems and psychological distress.
  • While some progress has been made in treating common causes of pruritus, many diseases remain overlooked and inadequately treated.
  • Barriers to effective treatment include the diverse nature of itching, difficulty in measuring it objectively, and challenges in identifying appropriate therapies for conditions like autoimmune diseases and others with high unmet needs.
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In 2022, Houston, TX became a nexus for field campaigns aiming to further our understanding of the feedbacks between convective clouds, aerosols and atmospheric boundary layer (ABL) properties. Houston's proximity to the Gulf of Mexico and Galveston Bay motivated the collection of spatially distributed observations to disentangle coastal and urban processes. This paper presents a value-added ABL dataset derived from observations collected by eight research teams over 46 days between 2 June - 18 September 2022.

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Article Synopsis
  • Pruritus, especially chronic itch, significantly affects quality of life and is driven by complex mechanisms depending on the underlying condition.
  • The article reviews current and emerging treatments for itch, focusing on drugs that have shown effectiveness in advanced clinical trials, targeting various inflammatory pathways and neural receptors.
  • There is a growing range of specialized therapies that not only address inflammation but also target the nervous system, reflecting rapid advancements in itch management.
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Aerosol acts as ice-nucleating particles (INPs) by catalyzing the formation of ice crystals in clouds at temperatures above the homogeneous nucleation threshold (-38 °C). In this study, we show that the immersion mode ice nucleation efficiency of the environmentally relevant protein, ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO), occurs at temperatures between -6.8 and -31.

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Pollen grains significantly contribute to the aerosol population, and levels are predicted to increase in the future. Under humid atmospheric conditions, pollen grains can rupture creating pollen grain fragments referred to as subpollen particles (SPPs) which are dispersed into the atmosphere with wind. In this laboratory study, SPP emission factors were determined for ryegrass, sp.

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  • Prurigo nodularis (PN) is a long-term skin condition characterized by itchy, thickened nodules, and its complex cause makes it hard to treat effectively.
  • This review focuses on nemolizumab, a new biological treatment for PN that targets inflammatory processes and has shown significant success in reducing itching and improving skin condition in recent studies.
  • Nemolizumab compares favorably to other treatments like dupilumab and is expected to work faster on itch; more research is needed to determine its long-term effectiveness and how it compares to other emerging medications.
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Aerosol acidity significantly influences heterogeneous chemical reactions and human health. Additionally, acidity may play a role in cloud formation by modifying the ice nucleation properties of inorganic and organic aerosols. In this work, we combined our well-established ice nucleation technique with Raman microspectroscopy to study ice nucleation in representative inorganic and organic aerosols across a range of pH conditions (pH -0.

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In-situ marine cloud droplet number concentrations (CDNCs), cloud condensation nuclei (CCN), and CCN proxies, based on particle sizes and optical properties, are accumulated from seven field campaigns: ACTIVATE; NAAMES; CAMPEX; ORACLES; SOCRATES; MARCUS; and CAPRICORN2. Each campaign involves aircraft measurements, ship-based measurements, or both. Measurements collected over the North and Central Atlantic, Indo-Pacific, and Southern Oceans, represent a range of clean to polluted conditions in various climate regimes.

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The phase states and glass transition temperatures () of secondary organic aerosol (SOA) particles are important to resolve for understanding the formation, growth, and fate of SOA as well as their cloud formation properties. Currently, there is a limited understanding of how changes with the composition of organic and inorganic components of atmospheric aerosol. Using broadband dielectric spectroscopy, we measured the of organic mixtures containing isoprene epoxydiol (IEPOX)-derived SOA components, including 2-methyltetrols (2-MT), 2-methyltetrol-sulfate (2-MTS), and 3-methyltetrol-sulfate (3-MTS).

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The substratum topography of both natural and synthetic materials is a prominent regulator of cell behaviors including adhesion, migration, matrix fibrillogenesis, and cell phenotype. Connective tissue fibroblasts are known to respond to repeating groove topographical modifications by aligning and exhibiting directed migration, a phenomenon termed contact guidance. Although both reside in collagen rich connective tissues, dermal and gingival fibroblasts are known to exhibit differences in phenotype during wound healing, with gingival tissue showing a fetal-like scarless response.

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Ocean aerobiology is defined here as the study of biological particles of marine origin, including living organisms, present in the atmosphere and their role in ecological, biogeochemical, and climate processes. Hundreds of trillions of microorganisms are exchanged between ocean and atmosphere daily. Within a few days, tropospheric transport potentially disperses microorganisms over continents and between oceans.

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Purpose: To assess whether meeting criteria for community ambulation and ambulatory self-confidence on discharge from inpatient rehabilitation are associated with participation in community activities.

Methods: Prospective longitudinal observational study design. Participants were assessed within 48-hours of discharge on ability to complete tasks reflective of community ambulation (walking 315 m, ascending/descending three stairs, a ramp, and a street curb and walking at 0.

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Purpose: We assessed the ability of patients discharging home from inpatient rehabilitation to meet criteria for community ambulation.

Methods: Cross-sectional observational study design. Participants were assessed, within 48-hours of discharge on their ability to: ascend/descend three steps, walk at a speed of 0.

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In healthy individuals, the healing of soft tissues such as skin after pathological insult or post injury follows a relatively predictable and defined series of cell and molecular processes to restore tissue architecture and function(s). Healing progresses through the phases of hemostasis, inflammation, proliferation, remodeling, and concomitant with re-epithelialization restores barrier function. Soft tissue healing is achieved through the spatiotemporal interplay of multiple different cell types including neutrophils, monocytes/macrophages, fibroblasts, endothelial cells/pericytes, and keratinocytes.

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Fractal particle morphologies are employed to study the light scattering properties of soot-laden mineral dust aerosols. The applicability of these models is assessed in comparison with measurements and other numerical studies. To quantify the dust-soot mixing effects on the single and multiple scattering properties, a parameterization of the effective bulk properties is developed.

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The role of marine bioaerosols in cloud formation and climate is currently so uncertain that even the sign of the climate forcing is unclear. Marine aerosols form through direct emissions and through the conversion of gas-phase emissions to aerosols in the atmosphere. The composition and size of aerosols determine how effective they are in catalyzing the formation of water droplets and ice crystals in clouds by acting as cloud condensation nuclei and ice nucleating particles, respectively.

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