Publications by authors named "Sarah Bowrey"
Objectives: Randomised controlled trial of the effect of a perineural infusion of levobupivacaine on moderate/severe phantom limb pain 6 months after major lower limb amputation.
Setting: Single-centre, UK university hospital.
Participants: Ninety patients undergoing above-knee and below-knee amputation for chronic limb threatening ischaemia under general anaesthesia.
Dysregulated host responses to infection can lead to organ dysfunction and sepsis, causing millions of global deaths each year. To alleviate this burden, improved prognostication and biomarkers of response are urgently needed. We investigated the use of whole-blood transcriptomics for stratification of patients with severe infection by integrating data from 3149 samples from patients with sepsis due to community-acquired pneumonia or fecal peritonitis admitted to intensive care and healthy individuals into a gene expression reference map.
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- A retrospective study of 338 lower limb amputee patients was conducted to identify factors affecting rehabilitation success with prosthetic limbs and resulted in the development of a scoring tool called the BLARt score.
- The tool was validated on 199 patients, showing that a BLARt score of ≥13 indicated a lack of good functional outcomes, with only a few achieving any level of independent walking.
- The BLARt score is a simple and effective tool that could help both patients and clinicians set realistic expectations for walking ability after surgery, highlighting the psychological and physical challenges amputees face during rehabilitation.
Article Synopsis
- Nursing practice should rely on credible evidence, and education should prepare nurses to question practices, critically analyze research, and apply findings to patient care.
- Health professionals engage with patients in clinical trials and contribute to enhancing care through a solid evidence foundation.
- The article discusses research nurses’ responsibilities in clinical trials, focuses on patient safety, and covers regulatory frameworks, consent processes, and ethical standards in clinical research.
Background And Objectives: Nociceptin/Orphanin FQ (N/OFQ) is a non-classical endogenous opioid peptide that modulates immune function in vitro. Its importance in inflammation and human sepsis is unknown. The objectives of this study were to determine the relationship between N/OFQ, transcripts for its precursor (pre-pro-N/OFQ [ppNOC]) and receptor (NOP), inflammatory markers and clinical outcomes in patients undergoing cardiopulmonary bypass and with sepsis.
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- This unit covers the use of spinal opioids for managing postoperative pain, divided into two parts for clarity.
- Part 1 focuses on the pharmacology of these opioids and discusses potential adverse effects associated with their use.
- Additional resources, including spinal anatomy details and a comparison table of spinal anaesthesia vs. analgesia and epidural analgesia, can be found in the Portfolio Pages on nursingtimes.net.
This is a two-part unit on using spinal opioids to manage postoperative pain. Part 1 outlined the pharmacology of spinal opioids. Part 2 discusses the selection of patients and their nursing care.
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