Publications by authors named "Sarah Barhouma"
Background: Pediatric acute liver failure (PALF) is an emergency, necessitating prompt referral and management at an experienced liver transplant center. Social determinants of health (SDOH) drive healthcare disparities and can affect many aspects of disease presentation, access to care, and ultimately clinical outcomes. Potential associations between SDOH and PALF outcomes, including spontaneous recovery (SR), liver transplant (LT) or death, are unknown.
View Article and Find Full Text PDFBackground: Pediatric acute liver failure (PALF) can require emergent liver transplantation (LT, >25%) or lead to death (~15%). Existing models cannot predict clinical trajectory or survival with native liver (SNL). We aimed to create a predictive model for PALF clinical outcomes based on admission variables.
View Article and Find Full Text PDFArticle Synopsis
- - Pediatric liver transplant recipients who received maternal living liver donor grafts (maternal-LLD) showed significantly lower rates of organ rejection compared to those who received deceased donor liver transplants (DDLT).
- - The study found that maternal-LLD recipients were more likely to be on simpler immunosuppression regimens and less likely to develop donor-specific antibodies (DSA) after transplantation.
- - Overall, the results suggest that using maternal-LLD for pediatric liver transplants has immunologic advantages, leading to improved outcomes versus DDLT.
Unlabelled: Reduced-size deceased donors and living donor liver transplantation (LDLT) can address the organ shortage for pediatric liver transplant candidates, but concerns regarding technical challenges and the risk of complications using these grafts have been raised. The aim of this study was to compare outcomes for pediatric LDLT and deceased donor liver transplantation (DDLT) via systematic review.
Methods: A systematic literature search was performed to identify studies reporting outcomes of pediatric (<18 y) LDLT and DDLT published between 2005 and 2019.