Exploring sleep-related disorders in patients with multiple sclerosis: A questionnaire-based approach.

Background: Multiple sclerosis (MS) is considered the most prevalent neurological disorder in young adults with many patients manifesting sleep-related disorders (SRD) due to its pathomechanisms. This is subsequently reflected in patients' quality of life and physical activities.

Material And Methods: This is a cross-sectional study at a tertiary care center.

Socioeconomic Disparities in Diagnosis-to-Treatment Time Among Patients Diagnosed With Breast Cancer in Saudi Arabia: A Cross-Sectional Study in a Tertiary Care Center.

Introduction Despite Saudi Arabia's' free healthcare system, breast cancer (BC) has a major impact on affected individuals. Previous studies have shown that socioeconomic variables could contribute to inequities in receiving treatment. Although early detection and treatment are essential, delays are frequently influenced by either insurance status or other socioeconomic variables.

pathogenic variant: genomic-phenotypic analysis.

The mediator complex subunit 23 () gene encodes a protein that acts as a tail module mediator complex, a multi-subunit co-activator involved in several cellular activities. has been shown to have substantial roles in myogenesis and other molecular mechanisms. The functions of in the neurological system remain unclear and the clinical phenotype is not thoroughly described.

The magnitude of influence of personal and professional factors on the career choices of medical students.

Medical students face uncertainty in choosing their future careers, which is influenced by personal and professional factors and can have a direct impact on the healthcare system and society. In this study, we aimed to analyze the magnitude of influence of personal and professional factors on students' choices of a future specialty, among medical students in Saudi Arabia and other Arab countries. This cross-sectional exploratory study used cluster sampling and collected demographic data, influencing factors, preferred specialty, and engagement level, using a 20-item questionnaire.

Clinical description and evaluation of 30 pediatric patients with ultra-rare diseases: A multicenter study with real-world data from Saudi Arabia.

Background: With the advancement of next-generation sequencing, clinicians are now able to detect ultra-rare mutations that are barely encountered by the majority of physicians. Ultra-rare and rare diseases cumulatively acquire a prevalence equivalent to type 2 diabetes with 80% being genetic in origin and more prevalent among high consanguinity communities including Saudi Arabia. The challenge of these diseases is the ability to predict their prevalence and define clear phenotypic features.

Childhood-related neural genotype-phenotype in ATP1A3 mutations: comprehensive analysis.

Background: ATP1A3 is a gene that encodes the ATPase Na + /K + transporting subunit alpha-3 isoenzyme that is widely expressed in GABAergic neurons. It maintains metabolic balance and neurotransmitter movement. These pathways are essential for the proper functioning of the nervous system.

GAMT Deficiency Among Pediatric Population: Clinical and Molecular Characteristics and Management.

Analyze the treatment modalities used in real practice by synthesizing available literature. We reviewed and evaluated 52 cases of GAMT deficiency including 4 novel cases from Saudi Arabia diagnosed using whole-exome sequencing. All data utilized graphical presentation in the form of line charts and illustrated graphs.

Accuracy of Ultrasound and Computed Tomography in Diagnosing Acute Cholecystitis Patients in a Tertiary Care Center in Saudi Arabia.

Background Acute cholecystitis (AC) is a gallbladder inflammatory disease often associated with gallbladder stones. It accounts for up to 5% of emergency department visits. The majority of patients present with pain in the right upper quadrant, Murphy's sign, and fever.