Depression-related disturbances in rat maternal behaviour are associated with altered monoamine levels within mesocorticolimbic structures.

The ability of mothers to sensitively attune their maternal responses to the needs of their developing young is fundamental to a healthy mother-young relationship. The biological mechanisms that govern how mothers adjust caregiving to the dynamic changes in the demands of the young remain an open question. In the present study, we examined whether changes in monoamine levels, within discrete mesocorticolimbic structures involved in cognitive and motivational processes key to parenting, modulate this flexibility in caregiving across the postpartum period.