Publications by authors named "Sarah Altmeyer"
Article Synopsis
- Macrophages play a crucial role in the effectiveness of the anti-CD19 antibody tafasitamab, which is used to treat certain types of lymphoma.
- The study focuses on the CD47-SIRPα interaction, which can inhibit the macrophages' ability to effectively eliminate tumor cells, and suggests that blocking CD47 may boost tafasitamab's effectiveness.
- Experimental results showed that combining tafasitamab with an anti-CD47 antibody improved phagocytosis of lymphoma cells and resulted in better outcomes in animal models, indicating potential for clinical application.
Patients undergoing intensive chemotherapy are usually in need for central venous catheters (CVC). Due to contradictory study results, relation of insertion site and CVC-associated complication rate in these patients is not clear. We therefore retrospectively analyzed CVC-related data of all patients undergoing intensive chemotherapy with high risk of febrile neutropenia according to NCCN criteria, who received a CVC at our bone marrow transplantation unit between May 2016 and December 2019.
View Article and Find Full Text PDFTo address the role of chronic antigenic stimulation in primary central nervous system lymphoma (PCNSL), we searched for autoantigens and identified sterile α-motif domain containing protein 14 (SAMD14) and neural tissue-specific F-actin binding protein I (neurabin-I) as autoantigenic targets of the B-cell receptors (BCRs) from 8/12 PCNSLs. In the respective cases, SAMD14 and neurabin-I were atypically hyper--glycosylated (SAMD14 at ASN339 and neurabin-I at ASN1277), explaining their autoimmunogenicity. SAMD14 and neurabin-I induced BCR pathway activation and proliferation of aggressive lymphoma cell lines transfected with SAMD14- and neurabin-I-reactive BCRs.
View Article and Find Full Text PDFObjective: Melatonin is known to influence immune functions and to ameliorate outcome after septic challenge but it is unknown whether this is mediated by melatonin receptor activation. This study aimed to elucidate molecular differences in spleen and ex vivo splenocytes of wild-type (WT) and melatonin receptor double knockout mice (KO) after polymicrobial sepsis.
Subjects And Methods: C3H/HeN wild-type and MT1-/-/MT2-/- mice underwent sham operation or cecum ligation and incision (CLI) and remained anesthetized for 1 h.