Value of routine blood count surveillance in detecting relapse in acute lymphoblastic leukemia.

Background: Children with acute lymphoblastic leukemia (ALL) have excellent outcomes, with >85% survival without relapse following contemporary therapies. Clinical and complete blood count (CBC) assessments are commonly used surveillance methods to detect relapses. We aimed to evaluate the efficacy of routine blood testing for detecting relapse using a systematic method of assessing normal and abnormal results.

The Impact of Silver Nanoparticles' Size on Biofilm Eradication.

Introduction: Efficient intracanal disinfection is required for a successful regenerative endodontic treatment. Thus, this study aimed to identify the silver nanoparticles' (NPs) size (AgNPs) with the highest antibiofilm efficacy when mixed with calcium hydroxide [Ca(OH)] to eradicate an in vitro endodontic biofilm.

Methods: The various sizes of AgNPs and mixtures were characterized by scanning electron microscopy, transmission electron microscopy, and ultraviolet-visible spectroscopy.

Characterizing a standardized BioPart for BAG-specific expression in .

Biological parts (BioParts) are modular and standardized DNA sequences that encode biological functions and contribute to the efficient biological engineering of complex systems. Here, we characterize a short BioPart (P , 300 bp) for bright multicopy and single-copy BAG-specific expression starting from the gastrula stage in hermaphrodite and male . We have generated standardized P cloning vectors for BAG-specific and expression compatible with extra-chromosomal arrays and for single-copy transgene insertion.

Pattern of Antibiotic Use Among Children With Acute Respiratory Infections in Saudi Arabia: Clinical Assessment.

Objectives: This study aimed to evaluate the common clinical diagnoses and treatment management of acute respiratory infections (ARIs) in children and determine when antibiotics are recommended and prescribed.

Methods: A retrospective review of medical charts was carried out at King Salman Bin Abdulaziz Medical City (KSAMC) Hospital to assess pediatric patients diagnosed with ARIs aged 0-14 years, excluding those requiring antibiotics for conditions other than ARIs. Data, including demographic diagnoses and treatment management, were extracted using consecutive sampling, and statistical analyses were conducted using Jamovi software.

The Relationship between Vitamin D Levels and Blood Glucose and Cholesterol Levels.

Background: Vitamin D deficiency has reached epidemic proportions globally. Observational data link low vitamin D status to diabetes, dyslipidemia, and metabolic syndrome, but interventional trials on the effects of supplementation are limited.

Objective: We investigated associations between serum 25-hydroxyvitamin D (25(OH)D) levels and metabolic markers in Saudi adults.

Characterizing a standardized BioPart for PVQ-specific expression in .

Synthetic biology relies on standardized biological parts (BioParts), and we aim to identify cell-specific promoters for every class of neuron in . Here, we characterize a short BioPart (P , 300 bp) for PVQ-specific expression. P showed bright, persistent, and specific expression in hermaphrodite and male PVQ neurons from multicopy arrays and single-copy insertions starting from the comma stage.

Acute and inherited piRNA-mediated silencing in a ribonucleotidyltransferase mutant.

We recently developed a piRNA-based silencing assay (piRNAi) to study small-RNA mediated epigenetic silencing: acute gene silencing is induced by synthetic piRNAs expressed from extra-chromosomal array and transgenerational inheritance can be quantified after array loss. The assay allows inheritance assays by injecting piRNAs directly into mutant animals and targeting endogenous genes ( , and ) with obvious phenotypes (increased male frequency). Here we demonstrate the piRNAi assay by quantifying acute and inherited silencing in the ribonucleotidyltransferase mutant.

A novel nanocomposite with superior electrocatalytic activity: A magnetic property based ZnFeO nanocubes embellished with reduced graphene oxide by facile ultrasonic approach.

Herein, a novel Zinc Ferrite nanocubes (ZnFeO NCs) decorated reduced graphene oxide (rGO) nanocomposite have been designed through a sonochemical method. After then, as-synthesized ZnFeO NCs/rGO was characterized by XPS, XRD, HRTEM and EIS. Furthermore, the ZnFeO NCs/rGO nanocomposite modified GCE (glassy carbon electrode) shows excellent electrochemical sensing performance towards biomarker of 4-nitroquinoline N-oxide (4-NQ) with fast detection.