Publications by authors named "Sarah Akiror"
Background & Aims: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by progressive inflammatory and fibrotic injury to the biliary tree. We sought to further delineate the contribution of macrophage lineages in PSC pathobiology.
Methods: Human liver tissues and/or blood samples from patients with PSC, primary biliary cholangitis, other non-cholestatic/non-autoimmune diseases, including alcohol-related liver disease and non-alcoholic steatohepatitis, as well as normal liver, were sourced from our liver transplantation program.
Please be advised that one of the author names is incorrectly spelled in the published article: 'Irene Kyomuhagi' should be 'Irene Kyomuhangi'.
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- * The study investigates the IL-12 signaling pathway in PBC, comparing blood samples from PBC patients to those with other autoimmune conditions and healthy individuals; results show increased IL-12 production in PBC and primary Sjögren's syndrome (pSS) monocytes versus controls.
- * Patients with PBC and pSS exhibit a stronger Treg response to IL-12, with notable increases in interferon-gamma production and activation of signaling
Background: Scale-up of malaria interventions seems to have contributed to a decline in the disease but other factors may also have had some role. Understanding changes in transmission and determinant factors will help to adapt control strategies accordingly.
Methods: Four sites in Ethiopia and Uganda were set up to monitor epidemiological changes and effectiveness of interventions over time.