Publications by authors named "Sarah A Whiteside"
Growth and division are two of the most fundamental capabilities of a bacterial cell. While they are well described for model organisms growing in broth culture, very little is known about the cell division cycle of bacteria replicating in more complex environments. Using a D-alanine reporter strategy, we found that intracellular Listeria monocytogenes (Lm) spend a smaller proportion of their cell cycle dividing compared to Lm growing in broth culture.
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- Pseudomonas aeruginosa is a harmful bacterium that infects various body parts, particularly in people with cystic fibrosis (CF), as it takes advantage of the compromised epithelial cells.
- This study investigates how P. aeruginosa induces the formation of blebs (bulges) in infected cells, revealing that this process is independent of actin and can be influenced by osmotic conditions, particularly involving the cystic fibrosis transmembrane-conductance regulator (CFTR).
- Findings reveal that CFTR-deficient cells have increased formation of these blebs, helping P. aeruginosa replicate and persist in the host, highlighting a potential pathway for bacterial survival during infection.