Publications by authors named "Sarah A Major"
Objective: Rapid ascent to altitude can result in the development of high altitude illnesses such as acute mountain sickness (AMS). This study aimed to investigate AMS symptoms in adolescents and study basic cardiopulmonary measurements at altitude.
Methods: Thirty-eight adolescents aged 16 to 19 years flew to 3500 m from 215 m and continued over a 23-day period to ascend to a maximum altitude of 5200 m.
Article Synopsis
- The K homology (KH) module is a common RNA-binding motif found in various regulatory proteins across prokaryotes and eukaryotes, with evidence pointing towards its self-aggregation having a significant functional role.
- Researchers focused on the Nova-1 KH3 domain to study its behavior in solution, revealing that it can self-associate (homodimerize) even without RNA present, indicating a specific protein/protein interaction.
- The study also examined how Nova-1 KH3 behaves both alone and when bound to RNA, which aids in understanding the mechanism of KH/RNA recognition and highlights the functional importance of dimerization in KH proteins across the entire KH family.