The interplay of intracellular calcium and zinc ions in response to electric field stimulation in primary rat cortical neurons .

Recent pharmacological studies demonstrate a role for zinc (Zn) in shaping intracellular calcium (Ca) dynamics and vice versa in excitable cells including neurons and cardiomyocytes. Herein, we sought to examine the dynamic of intracellular release of Ca and Zn upon modifying excitability of primary rat cortical neurons using electric field stimulation (EFS) . We show that exposure to EFS with an intensity of 7.