Publications by authors named "Saraca L"
Background: This study aims to investigate the activity of the remdesivir-nirmatrelvir combination against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and to report a case of Coronavirus Disease 2019 (COVID-19) cured with this combination.
Methods: A Vero E6 cell-based infection assay was used to investigate the in vitro activity of the remdesivir-nirmatrelvir combination. The SARS-CoV-2 strains tested were 20A.
Article Synopsis
- SARS-CoV-2 is the virus causing COVID-19, and it can lead to a dangerous inflammatory response known as a "cytokine storm" (CS), which significantly worsens patient outcomes.
- A new "Cytokine Storm Score" (CSs) has been proposed to identify COVID-19 patients at risk of severe hyperinflammation, enabling timely treatment to improve survival rates.
- Research conducted at St. Maria Hospital analyzed patients with confirmed SARS-CoV-2 infections to validate the CSs, aiming to promptly manage cases to prevent severe complications, such as intubation.
In recent years, a decrease in the incidence of tuberculosis (TB) has been recorded worldwide. However, an increase in TB cases has been reported in foreign people living in low-incidence countries, with an increase in extrapulmonary TB (EPTB) in the western region of the world. In the present work, a retrospective study was conducted in two Italian infectious diseases wards to evaluate the clinical characteristics of TB admission in the time period 2013-2017.
View Article and Find Full Text PDFUse of Ceftolozane-Tazobactam in Patient with Severe Medium Chronic Purulent Otitis by XDR .
Case Rep Infect Dis
October 2019
We present a case of a male Italian patient of 66 years with a history of kidney transplantation in treatment with cyclosporine and methylprednisolone. He visited an ENT clinic and was diagnosed as chronic left purulent otitis media. He began at-home antibiotic therapy with poor benefit.
View Article and Find Full Text PDFArticle Synopsis
- Listeria monocytogenes (LM) is an opportunistic pathogen that primarily causes meningitis, with brain abscesses being rare occurrences, only 73 reported cases from 1968 to 2017.
- The average age of affected patients is about 52 years, with a mortality rate of 27.3%; one-fifth of these patients had no identifiable risk factors.
- Treatment approaches varied, with surgery and longer medical therapy linked to lower mortality rates, suggesting that a combination of surgical intervention and extended treatment may improve outcomes.
Myocarditis is an inflammatory disease of the myocardium. Viruses, such as enterovirus, adenovirus, parvovirus B19, HHV6 or cytomegalovirus (CMV) and autoimmune diseases are recognized causes of myocarditis. We describe the clinical case of a young Indian woman with SLE and a concomitant acute CMV related myocarditis with favourable outcome after ganciclovir therapy.
View Article and Find Full Text PDFLemierre's syndrome is a dangerous potential sequela of pharyngitis that results in septic thrombophlebitis of the internal jugular vein. A high index of suspicion is needed to consider this diagnosis in the workup of pharyngitis and should be aggressively treated once. Gram-negative anaerobic bacteria, mainly Fusobacterium necrophorum are implicated.
View Article and Find Full Text PDFThe extra-pulmonary tuberculosis (TB) constitutes to about 20% of all TB cases. Among extra-pulmonary form, splenic TB is very rare clinical condition especially as initial manifestation in a developed country. Diagnosis of splenic TB is challenging because it presents no specific symptoms or typical imaging findings and microbiological confirmation is not straight forward.
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