Publications by authors named "Sarab Taha"
J Clin Invest
January 2021
Article Synopsis
- Zeb1 is a transcription factor that plays a crucial role in maintaining adult hematopoietic stem cells (HSCs), as its deletion leads to rapid thymic atrophy and increased cell death in T cells.
- The loss of Zeb1 results in severe self-renewal defects and an inability to differentiate into multiple lineages, indicating its essential function in HSC maintenance.
- Zeb1 also exhibits tumor suppressor properties in acute myeloid leukemia (AML) by regulating gene expression related to HSC function and preventing the aggressive progression of leukemic stem cells.
