Hyperbaric Oxygen Enabled a Transition to Oral Steroids in an Acute Severe Ulcerative Colitis Flare.

Background: Ulcerative colitis (UC) is characterized in part by a dysregulated response to tissue hypoxia. While intravenous (IV) steroids are the mainstay of treatment for acute severe UC (ASUC), up to one-third of patients are refractory to steroids alone and require rescue therapy.

Case Description: A 71-year-old female with extensive UC on infliximab presented with abdominal pain and more than 10 bloody bowel movements per day.

A Rare Case of Waldenstrom Macroglobulinemia of the Rectosigmoid Colon.

Waldenstrom macroglobulinemia is an uncommon mature B-cell lymphoma characterized by monoclonal immunoglobulin M protein in peripheral blood and lymphoplasmacytic cells in bone marrow and/or extramedullary sites. The gastrointestinal tract is a rare site of involvement. The diagnosis is based on clinicopathologic findings, although somatic mutations, such as MYD88, can aid in the diagnosis.

Alcoholic Hepatitis and COVID-19: The Question of Steroids.

Severe acute respiratory syndrome coronavirus 2/novel coronavirus-19 (COVID-19) has rapidly become a global pandemic since the first cases from Wuhan, China, were reported in December 2019. The pandemic has made it more challenging to treat various gastrointestinal disorders, including acute alcoholic hepatitis (AH). One of the mainstays of treatment for severe AH involves corticosteroids (mainly prednisolone).