Publications by authors named "Sara Yoder"
Article Synopsis
- Lineage plasticity in cancer affects treatment effectiveness, and this study presents a new in vivo method to explore neuroendocrine lineage changes in prostate cancer progression.* -
- Researchers found that mouse prostate organoids with specific mutations form aggressive neuroendocrine prostate cancer (NEPC) when Rb1 is deleted, but only in the right in vivo environment, unlike traditional organoid cultures.* -
- The study shows that ASCL1 cells originate from KRT8 luminal cells and that losing Ascl1 in NEPC leads to temporary regression but later recurrence; however, deleting it before transplantation prevents lineage changes and results in more treatable adenocarcinomas.*
Lineage plasticity is a recognized hallmark of cancer progression that can shape therapy outcomes. The underlying cellular and molecular mechanisms mediating lineage plasticity remain poorly understood. Here, we describe a versatile platform to identify and interrogate the molecular determinants of neuroendocrine lineage transformation at different stages of prostate cancer progression.
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