Publications by authors named "Sara Trnski-Levak"
Article Synopsis
- Perineuronal nets (PNNs) are crucial components of the extracellular matrix that influence synaptic activity and plasticity within interneurons, which are important for brain function and can be affected by disease.
- In a study of 25 human brains, researchers found that different types of PNNs varied in their distribution across cortical layers, with VCAN and NCAN-expressing PNNs predominantly in layers I and VI, while WFA-binding PNNs were more common in layers III-V.
- The team observed significant differences in PNN characteristics based on region and lamination, suggesting that PNNs contribute to the formation of specific microcircuits in the human cortex
Introduction: Adversities during the perinatal period can decrease oxygen supply to the fetal brain, leading to various hypoxic brain injuries, which can compromise the regularity of brain development in different aspects. To examine the catecholaminergic contribution to the link between an early-life hypoxic insult and adolescent behavioral aberrations, we used a previously established rat model of perinatal hypoxia but altered the hypobaric to normobaric conditions.
Methods: Exploratory and social behavior and learning abilities were tested in 70 rats of both sexes at adolescent age.