Publications by authors named "Sara Suleiman"
Metabarcoding analysis of oral microbiome during pregnancy.
Front Cell Infect Microbiol
January 2025
Article Synopsis
- Pregnancy involves significant hormonal and metabolic changes to support fetal development, which the study investigates through changes in the salivary microbiome and biochemical markers between the second and third trimesters.
- Saliva samples from 45 pregnant women were analyzed using advanced DNA sequencing techniques, revealing notable shifts in microbial diversity, including a 3-fold increase in Bacteroidota and changes in other microbial taxa.
- Biochemical changes included increased BMI, pulse rate, glucose, and cholesterol levels in the third trimester, along with correlations between these factors and microbial abundance, emphasizing the need for monitoring oral health and metabolic health during pregnancy.
In recent years, it has become clear that microbiome play a variety of essential roles in human metabolism, immunity, and overall health and that the composition of these microbiome is influenced by our environment, diet, weight, hormones, and other factors. Indeed, numerous physiological and pathological conditions, including obesity and metabolic syndrome, are associated with changes in our microbiome, referred to as dysbiosis. As a result, it is not surprising that such changes occur during pregnancy, which includes substantial weight gain and significant changes in metabolism and immune defenses.
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