Publications by authors named "Sara Stankovic"
Int J Mol Sci
September 2024
Article Synopsis
- Phenylketonuria (PKU) is a genetic disorder that leads to high levels of phenylalanine, causing cognitive issues if untreated, but the exact brain effects of this condition are still unclear.
- This study used a new model of NT2-derived neurons treated with varying concentrations of phenylalanine to investigate gene expression changes linked to PKU-related brain impairment.
- The research found that specific genes were altered in response to phenylalanine, affecting neuronal processes like dendrite and axon development, ultimately highlighting the neurotoxic effects of high phenylalanine levels.
