The role of tyrosine sulfation in the dimerization of the CXCR4:SDF-1 complex.

Oligomerization of G protein-coupled receptors is a recognized mode of regulation of receptor activities, with alternate oligomeric states resulting in different signaling functions. The CXCR4 chemokine receptor is a G protein-coupled receptor that is post-translationally modified by tyrosine sulfation at three sites on its N-terminus (Y7, Y12, Y21), leading to enhanced affinity for its ligand, stromal cell derived factor (SDF-1, also called CXCL12). The complex has been implicated in cancer metastasis and is a therapeutic target in cancer treatment.

Ulipristal acetate for emergency contraception.

Objective: To review the pharmacology, pharmacokinetics, efficacy, and safety of data of ulipristal acetate, a new emergency contraceptive approved for use up to 120 hours after unprotected intercourse.

Data Sources: Articles pertaining to the topic were identified and reviewed through searches of PubMed (1994-March 2011) and clinicaltrials.gov, using the key terms ulipristal and CDB-2914.

Trends in plasma transfusion at a veterinary teaching hospital: 308 patients (1996-1998 and 2006-2008).

Objectives: To describe changes in fresh frozen plasma (FFP) utilization over a 10-year period at a veterinary teaching hospital. To evaluate the effect of FFP administration on specific laboratory parameters.

Design: Retrospective observational study.

Use of technology to track program outcomes in a diabetes self-management program.

The Diabetes Self-Management Education Program at MetroHealth Medical Center in Cleveland, OH, uses widely available technology to facilitate outcomes tracking and market the diabetes program. Baseline assessment data are entered directly into an Access database form (Microsoft, Inc, Seattle, WA). Quarterly, updated weight and lab data are downloaded into the database from the Epicare electronic medical record (Epic Systems Corp, Madison, WI).