Publications by authors named "Sara Snelling"
Identification of improved translatable biomarkers of nephrotoxicity is an unmet safety biomarker need. Fatty-acid-binding protein 4 (FABP4) was previously found to be associated with clinical renal dysfunction and was proposed as a biomarker of glomerular damage. The aim of this study was to evaluate FABP4 as a potential preclinical biomarker of drug-induced kidney injury (DIKI).
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- Drug-induced kidney injury (DIKI) is a major issue in drug development, and traditional urinary protein biomarkers have limitations, prompting interest in microRNAs (miRNAs) as potential alternatives.
- In a study involving Wistar rats treated with three nephrotoxic substances, specific miRNAs were found to be significantly dysregulated, indicating their potential as biomarkers for kidney injury targeting different nephron segments.
- The findings suggest that combining urinary miRNAs with protein biomarkers could improve the detection of kidney damage during drug testing, enhancing our understanding of DIKI in preclinical studies.