Publications by authors named "Sara Shoushtari"
Article Synopsis
- T helper 1 (Th1)-mediated immune rejection is the main reason for graft failure after transplantation, influenced by interactions between different types of dendritic cells, particularly CD11b+ DC2 and CD103+ DC1.
- In non-inflamed corneal beds, migratory CD103+ DC1 cells maintain a tolerogenic function that helps suppress harmful immune responses and promote graft survival through mechanisms like IL-10 and the PD-L1/PD-1 pathway.
- In contrast, in inflamed corneal beds, Th1 cells switch CD103+ DC1 cells to an immunostimulatory state, leading to graft failure; however, transferring tolerogenic CD103+ DC1s can inhibit this negative
Article Synopsis
- Diabetes mellitus (DM) is a widespread and rapidly increasing disease, with many long-term patients experiencing diabetic keratopathy (DK), although the inflammatory mechanisms behind DK remain unclear.
- Research using mouse models for type 1 and type 2 DM showed increased levels of certain myeloid immune cells and proinflammatory cytokines (TNF-α and IL-1β) in the cornea after four weeks, indicating an inflammatory response.
- Clinical symptoms of DK, such as reduced tear production and corneal sensitivity, were noted alongside lower nerve density in the corneal area of diabetic mice, suggesting that DM disrupts the normal immune status of the cornea, contributing to DK development.
Prevalence and Determinants of Unmet Social Needs Among Rural and Urban Veterans.
J Health Care Poor Underserved
July 2023
Purpose: To examine the prevalence and determinants of nine unmet social needs among rural compared with urban Veterans.
Methods: Retrospective study using survey data collected in 2020 merged with Veterans Health Administration (VA) administrative data. For each unmet need, separate logistic regression modes were run predicting the odds of rural compared with urban Veterans endorsing the need adjusting for sociodemographic characteristics and comorbidities.
Bone Formation in a Mucinous Cystadenoma of the Ovary - Report of a Rare Case.
Maedica (Bucur)
September 2021
Bone formation in the ovary is exceedingly rare, except in the setting of dermoid cysts. Here, the author reports a case of incidental finding of heterotopic bone formation in a mucinous cystadenoma of the ovary in a 45-year-old woman who had underwent a total abdominal hysterectomy and right salpingo-oopherectomy because of hypermenorrhea during last one year with an ultrasonography report of right ovarian cyst and simultaneous multiple uterine leiomyomatas. Microscopic examination of the ovarian cyst revealed a mucinous cystadenoma with the striking finding of several thin plates of lamellar bone identified in fibrous tissue in the cyst wall.
View Article and Find Full Text PDFProtein synthesis is an essential process that affects major cellular functions including growth, energy production, cell signaling, and enzymatic reactions. However, how it is impacted by aging and how the translation of specific proteins is changed during the aging process remain understudied. Although yeast is a widely used model for studying eukaryotic aging, analysis of age-related translational changes using ribosome profiling in this organism has been challenging due to the need for isolating large quantities of old cells.
View Article and Find Full Text PDF