Publications by authors named "Sara Sadat Aghabozorg Afjeh"
Article Synopsis
- The study investigates the link between HLA allele diversity and the severity of COVID-19 in Iranian patients, comparing 100 individuals with severe cases to 100 with mild cases.
- HLA typing revealed that certain alleles (HLA-A*11 and HLA-DRB1*14) were more common in severe cases, while HLA-B*52 was found more frequently in mild cases.
- The findings suggest that specific HLA alleles can influence COVID-19 outcomes, offering insights that could aid in patient management and understanding of the disease.
Article Synopsis
- Lithium is a common treatment for bipolar disorder, but 10-60% of patients may not respond well to it.
- A study investigated the MARK2 gene's impact on lithium response in Iranian bipolar patients, finding a significant association between the MARK2 rs10792421 polymorphism and treatment outcomes.
- The results suggest that the A allele is linked to a better response to lithium, indicating that this genetic variant could serve as a potential biomarker for predicting treatment success in this population.
Bipolar disorder (BD) is a major health care concern worldwide. There are some reports showing an association between genes and their variants involved in circadian rhythm; clock and clock related genes function and development of BD in patients. Therefore, the aim of this study was to investigate the possible association of rs534654 variant on (transmembrane protein 165) gene with the risk of BD.
View Article and Find Full Text PDFBackground: Methadone therapy is a major protocol in opioid addiction cases in many health care systems. Population-based studies have shown that in addicted people, the genetic profile affects their response to methadone therapy. Therefore, this study designed to examine the frequency of two SNPs of the CYP2B6 gene (rs3745274 and rs3211371) in addicted cases in two methadone-responders and methadone non-responders groups.
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